- Glutarimide
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2026-09-14
- CAS:1121-89-7
- Min. Order: 25kgs/paper drum
- Purity: 99%
- Supply Ability: 10 tons
- Glutarimide
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- $8.80
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2026-08-25
- CAS:1121-89-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- Glutarimide
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-
2026-06-30
- CAS:1121-89-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
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| | Glutarimide Basic information |
| | Glutarimide Chemical Properties |
| Melting point | 155-157 °C (lit.) | | Boiling point | 211.82°C (rough estimate) | | density | 1.2416 (rough estimate) | | refractive index | 1.4200 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Chloroform, DCM | | form | Crystals or Crystalline Flakes | | pka | pKa 11.4 (Uncertain) | | color | White | | Water Solubility | Soluble in water, hot ethanol and boiling benzene. Insoluble in ether. | | BRN | 110052 | | InChI | InChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8) | | InChIKey | KNCYXPMJDCCGSJ-UHFFFAOYSA-N | | SMILES | N1C(=O)CCCC1=O | | CAS DataBase Reference | 1121-89-7(CAS DataBase Reference) | | EPA Substance Registry System | Glutarimide (1121-89-7) |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 37/39-26 | | WGK Germany | 3 | | RTECS | MA4000000 | | HS Code | 29251995 | | Storage Class | 11 - Combustible Solids |
| | Glutarimide Usage And Synthesis |
| Description | Glutarimide, also known as Piperidine-2,6-dione or 2,6-Piperidinedione, is a versatile and commonly used organic reagent, classified in pharmacology as a protein synthesis inhibitor compound. It is also an important component of the anti-cancer drug thalidomide. The study reported the synthesis of triazoloquinoxaline derivative (Compound 15), a new potent anticancer drug containing a glutarimide molecule, based on the CRBN binding property of the glutarimide molecule in thalidomide molecule and the cytotoxic activity of triazole-quinoxaline. The IC50s were 9.81 ± 0.7, 15.49 ± 1.2 and 10.09 ± 0.9 μM for hepatocellular carcinoma (HepG2), prostate cancer (PC3) and breast cancer (MCF-7), respectively. It was superior to thalidomide in decreasing NF-κB P65 levels in HepG-2 cells[1]. | | Chemical Properties | white crystalline powder | | Uses | Glutarimide acts as an inhibitor of protein synthesis. Further, it is used as a reactant for thionations and biocatalytic asymmetric synthesis of sitagliptin production. It is also employed in the generation of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids and alfa-fluoro-alfa amino amides. In addition to this, it is used in intramolecular amidocyclopropanation reactions. | | Definition | ChEBI: Glutarimide (Piperidine-2,6-dione) is a dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6. It is a member of piperidones and a dicarboximide. | | Preparation | To a flask containing 70 gm (0.53 mole) of glutaric acid is added 150 ml (2.2 mole) of 28% aqueous ammonia. The mixture is set for distillation and heated for 7 hr as the temperature of the mixture rises from 90° to 180°C. The temperature is held at 170-180°C for \\ hr or until the evolution of ammonia ceases. The reaction mixture solidifies on cooling and the product is recrystallized from acetone to afford 37.4 gm (63%), m.p. 145-146°C.
t may be advantageous to preform the ammonium salt of dicarboxylic acids prior to the application of enough heat to form the imide. The preparation of succinimide is a case in point.
 | | General Description | A glutarimide antibiotic, 9-methylstreptimidone, shows antiviral, antitumor and antifungal activities. | | Purification Methods | Purify it by dissolving 75g in 200mL of H2O, boil for 30minutes with 2g of charcoal, filter, evaporate to dryness and recystallise the residue from 125mL of 95% EtOH to give 70g of white crystals, m 152-154o. It also crystallises from Me2CO (m 163-165o) or EtOH (m 153-154o). The N-bromo derivative (a brominating agent) crystallises from H2O with m 180-185o. [Paris et al. Org Synth Coll Vol IV 496 1963, Beilstein 21 H 382, 21 I 331, 21 II 307, 21 III/IV 4582.] | | References | [1] MAGED MOHAMMED SALEH AL WARD . Design, synthesis and biological evaluation of newly triazolo-quinoxaline based potential immunomodulatory anticancer molecules[J]. Journal of Molecular Structure, 2023. DOI:10.1016/j.molstruc.2023.137041. |
| | Glutarimide Preparation Products And Raw materials |
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