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| | 1-(Triphenylmethyl)imidazole Basic information |
| | 1-(Triphenylmethyl)imidazole Chemical Properties |
| Melting point | 220-224 °C(lit.) | | Boiling point | 451.3±14.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 6.34±0.30(Predicted) | | color | White to Off-White | | Water Solubility | Insoluble in water. | | BRN | 238171 | | InChI | InChI=1S/C22H18N2/c1-4-10-19(11-5-1)22(24-17-16-23-18-24,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-18H | | InChIKey | NPZDCTUDQYGYQD-UHFFFAOYSA-N | | SMILES | C1N(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1 | | CAS DataBase Reference | 15469-97-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2933299090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-(Triphenylmethyl)imidazole Usage And Synthesis |
| Uses | 1-Tritylimidazole is a Clotrimazole (C587400) analog as antifungal agent. | | Uses | 1-(Triphenylmethyl)imidazole may be used in the synthesis of 1,2,5-trisubstituted imidazole derivatives. | | General Description | 1-(Triphenylmethyl)imidazole is an imidazole derivative. | | Synthesis | The reaction was carried out in a 50 L autoclave using imidazole (880 g, 12.9 mol, 1.0 eq.) and triphenylchloromethane (3605.0 g, 12.9 mol, 1.0 eq.) as raw materials. First, imidazole was dissolved in 12 L of DMF and cooled to below 0 °C. Subsequently, triethylamine (1308 g, 12.9 mol, 1.0 eq.) was added and the reaction was kept for 30 min. A DMF solution of triphenylchloromethane (16 L) was slowly added dropwise to the reaction mixture at 0°C. After the dropwise addition was completed, the reaction system was warmed to 15°C and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the reaction mixture was poured into water and a large amount of solid was precipitated. The solid was collected by filtration and the filter cake was washed with water, drained and dried to afford N-trityl imidazole (Compound XIV-1) as a white solid 3835.1 g in 95.6% yield. | | References | [1] Patent: CN104086553, 2016, B. Location in patent: Paragraph 0065-0068
[2] Patent: US2010/16610, 2010, A1. Location in patent: Page/Page column 28
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 253 - 256
[4] Tetrahedron, 1999, vol. 55, # 13, p. 4109 - 4122
[5] Patent: US6476216, 2002, B1 |
| | 1-(Triphenylmethyl)imidazole Preparation Products And Raw materials |
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