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| | 1-Tritylimidazole-4-carboxaldehyde Basic information |
| | 1-Tritylimidazole-4-carboxaldehyde Chemical Properties |
| Melting point | 180-190°C | | Boiling point | 502.8±45.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Acetonitrile (Slightly), Methanol (Slightly) | | pka | 2.28±0.61(Predicted) | | form | solid | | color | White to brown | | InChI | InChI=1S/C23H18N2O/c26-17-22-16-25(18-24-22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-18H | | InChIKey | YQYLLBSWWRWWAY-UHFFFAOYSA-N | | SMILES | C1N(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=C(C=O)N=1 | | CAS DataBase Reference | 33016-47-6(CAS DataBase Reference) |
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ALFA
| English |
| | 1-Tritylimidazole-4-carboxaldehyde Usage And Synthesis |
| Uses | 1-Tritylimidazole-4-carboxaldehyde is used in the synthesis of histamine and girolline | | Synthesis | Example 33: Synthesis of 1-trityl-1H-imidazole-4-carbaldehyde
4-Imidazolecarboxaldehyde (30.0 g, 0.30 mol) was dissolved in DMF (200 mL) and triethylamine (70 mL, 0.375 mol) was added slowly under cooling in an ice bath. Triphenylchloromethane (105 g, 0.375 mol) was then added in batches and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum evaporation and the residue was washed with anhydrous ether (4 x 50 mL) and dried to give a yellow solid 1-tritylimidazole-4-carboxaldehyde (100 g, 100%). | | References | [1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 23, p. 7993 - 8002
[2] Patent: WO2008/4096, 2008, A1. Location in patent: Page/Page column 79
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 1, p. 177 - 188
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 18, p. 3957 - 3962
[5] Patent: US2004/122018, 2004, A1. Location in patent: Page 317 |
| | 1-Tritylimidazole-4-carboxaldehyde Preparation Products And Raw materials |
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