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| | 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole Basic information |
| | 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole Chemical Properties |
| Boiling point | 290.1±20.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -2.29±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole Usage And Synthesis |
| Synthesis | To a solution of 4-nitro-1H-pyrazole (113 mg, 1 mmol, 1.0 eq.) in acetonitrile (5 mL) was added 2-bromoethyl methyl ether (138 mg, 1 mmol, 1.0 eq.) and potassium carbonate (276 mg, 2 mmol, 2.0 eq.) in that order. The reaction mixture was stirred at 80 °C for 4 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (100 mL) and washed with water (50 mL × 2). The organic layers were combined, concentrated and purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1) to afford 1-(2-methoxyethyl)-4-nitro-1H-pyrazole (170 mg, yield: 100%) as a colorless oil.ESI-MS (M + H): 172.1.1 1H NMR (400 MHz, CDCl3) δ: 8.23 (s, 1H) , 8.07 (s, 1H), 4.31 (t, J = 5.2 Hz, 2H), 3.74 (t, J = 5.2 Hz, 2H), 3.35 (s, 3H). | | References | [1] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0223
[2] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00078
[3] Patent: US2014/200206, 2014, A1. Location in patent: Paragraph 0339
[4] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 104 |
| | 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole Preparation Products And Raw materials |
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