ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride

8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride

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8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Suppliers list
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8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride manufacturers

  • (Rac)-WAY-161503
  • (Rac)-WAY-161503 pictures
  • $86.00
  • 2026-07-27
  • CAS:75704-24-4
  • Purity: 99.51%
  • Supply Ability: 10g
  • (Rac)-WAY-161503
  • (Rac)-WAY-161503 pictures
  • $86.00
  • 2026-07-27
  • CAS:75704-24-4
  • Purity: 99.51%
  • Supply Ability: 10g
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Basic information
Product Name:8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Synonyms:WAY 161503 HYDROCHLORIDE;WAY 161503;1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-;WAY 161503 hydrochlo;(Rac) WAY 161503,(Rac)WAY161503;8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
CAS:75704-24-4
MF:C11H11Cl2N3O
MW:272.13
EINECS:
Product Categories:Serotonin receptor
Mol File:75704-24-4.mol
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Structure
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Chemical Properties
Boiling point 513.9±50.0 °C(Predicted)
density 1.54±0.1 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
form A crystalline solid
pka12.09±0.20(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Usage And Synthesis
Uses8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one is a selective 5-hydroxytryptamine 2C receptor agonist with putative antidepressant like properties. It also blocks and decreases baseline nicotine-induced locomotor activity in rats.
Biological ActivityPotent and selective 5-HT 2C receptor agonist (K i = 4 nM; EC 50 = 12 nM). Antidepressant following systemic administration in vivo .
in vivo

(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082[1].

Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.
IC 505-HT2C Receptor: 4 nM (Ki); 5-HT2C Receptor: 12 nM (EC50)
8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride Preparation Products And Raw materials
Tag:8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride(75704-24-4) Related Product Information
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