| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
NCE Biomedical Co.,Ltd. |
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Email: |
|
|
| | JNK inhibitor Basic information |
| Product Name: | JNK inhibitor | | Synonyms: | 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;JNK-IN-7;JNK inhibitor;CS-2418;JNK inhibitor 7;Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-;JNK-IN-7 Only for R&D;(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide | | CAS: | 1408064-71-0 | | MF: | C28H27N7O2 | | MW: | 493.56 | | EINECS: | | | Product Categories: | MAPK | | Mol File: | 1408064-71-0.mol |  |
| | JNK inhibitor Chemical Properties |
| density | 1.301±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | 13.34±0.70(Predicted) | | color | White to gray |
| | JNK inhibitor Usage And Synthesis |
| Description | JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively). | | Uses | JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product. | | IC 50 | JNK3: 0.7 nM (IC50); JNK1: 1.5 nM (IC50); JNK2: 2 nM (IC50) | | references | [1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46. |
| | JNK inhibitor Preparation Products And Raw materials |
|