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Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl-

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Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- manufacturers

  • LPA2 antagonist 1
  • LPA2 antagonist 1 pictures
  • $278.00
  • 2026-08-08
  • CAS:1017606-66-4
  • Purity: 99.85%
  • Supply Ability: 10g
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Basic information
Product Name:Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl-
Synonyms:CS-1271;LPA2-IN-1;Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl-;LPA2 antagonist 1;N-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine;(S)-N-(1-(4-((3,4-Dichlorophenyl)sulfonyl)piperazin-1-yl)propan-2-yl)-7-methylthieno[3,2-d]pyrimidin-4-amine;LPA-2 antagonist 1,LPA2 antagonist 1
CAS:1017606-66-4
MF:C20H23Cl2N5O2S2
MW:500.46
EINECS:
Product Categories:
Mol File:1017606-66-4.mol
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Structure
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Chemical Properties
Boiling point 684.6±65.0 °C(Predicted)
density 1.453±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form Powder
pka6.52±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Usage And Synthesis
DescriptionLPA2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA2; IC50 = 17 nM). It is selective for LPA2 over LPA1 and LPA3 (IC50s = >50 μM). LPA2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner.
UsesN-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine is a Lpa2 protein antagonists.
References[1] HILARY P. BECK . Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 3: Pages 1037-1041. DOI: 10.1016/j.bmcl.2007.12.024
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Preparation Products And Raw materials
Tag:Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl-(1017606-66-4) Related Product Information
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