| Company Name: |
TOSUN PHARM |
| Tel: |
020-66392521-118 18922260391 |
| Email: |
3004261881@qq.com |
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| | Abacavir Related CoMpound D Basic information |
| Product Name: | Abacavir Related CoMpound D | | Synonyms: | Abacavir EP Imp B;Abacavir Related CoMpound D;N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine;Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine;Abacavir Impurity 2(Abacavir EP Impurity B);Abacavir EP Impurity B;O-Pyrimidine Derivative Abacavir (USP);6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine | | CAS: | 1443421-69-9 | | MF: | C18H21ClN10O | | MW: | 428.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1443421-69-9.mol |  |
| | Abacavir Related CoMpound D Chemical Properties |
| Boiling point | 830.1±75.0 °C(Predicted) | | density | 1.90±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.86±0.10(Predicted) | | Major Application | pharmaceutical | | InChIKey | GETKMSKGQYJOPI-SCZZXKLOSA-N | | SMILES | Clc1nc(nc(c1N)OC[C@H]2C[C@H](C=C2)[n]3c4nc(nc(c4nc3)NC5CC5)N)N |
| WGK Germany | 3 | | HS Code | 2933599550 | | Storage Class | 13 - Non Combustible Solids |
| | Abacavir Related CoMpound D Usage And Synthesis |
| Uses | Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| | Abacavir Related CoMpound D Preparation Products And Raw materials |
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