- XY1
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- $31.00 / 5mg
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2026-03-13
- CAS:1624117-53-8
- Min. Order:
- Purity: 99.00%
- Supply Ability: 10g
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| Product Name: | XY1 | | Synonyms: | XY1;XY-1 (Negative of SGC-707);XY1;XY-1;XY 1;CS-2431;1-(naphthalen-2-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea;XY1 NEW;N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea;XY1; XY 1 | | CAS: | 1624117-53-8 | | MF: | C17H19N3O2 | | MW: | 297.35 | | EINECS: | | | Product Categories: | API | | Mol File: | 1624117-53-8.mol |  |
| Boiling point | 514.8±42.0 °C(Predicted) | | density | 1.284±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 12.62±0.46(Predicted) | | color | White to off-white |
| Description | Protein arginine N-methyltransferase 3 (PRMT3, ) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 μM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 μM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information. | | Uses | XY1 acts as a close analog of SGC707 that is completely inactive against PRMT3, inhibiting the methylation of histones in cells. | | storage | Store at +4°C | | References | [1] J TANG. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation.[J]. The Journal of Biological Chemistry, 1998, 273 27: 16935-16945. DOI: 10.1074/jbc.273.27.16935
[2] WOLF S S. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans.[J]. Cellular and Molecular Life Sciences, 2009, 66 13: 2109-2121. DOI: 10.1007/s00018-009-0010-x
[3] DR. H. üMIT KANISKAN. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)[J]. Angewandte Chemie International Edition, 2015, 54 17: 5166-5170. DOI: 10.1002/anie.201412154 |
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