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| | Bromo-PEG5-phosphonic acid ethyl ester Basic information |
| Product Name: | Bromo-PEG5-phosphonic acid ethyl ester | | Synonyms: | Bromo-PEG5-phosphonic acid ethyl ester;Bromo-PEG5-phosphonic acid diethyl ester;Phosphonic acid, P-(17-bromo-3,6,9,12,15-pentaoxaheptadec-1-yl)-, diethyl ester;Bromo-peg5-ethyl phosphate | | CAS: | 1446282-41-2 | | MF: | C16H34BrO8P | | MW: | 465.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1446282-41-2.mol |  |
| | Bromo-PEG5-phosphonic acid ethyl ester Chemical Properties |
| | Bromo-PEG5-phosphonic acid ethyl ester Usage And Synthesis |
| Description | Bromo-PEG5-phosphonic acid diethyl ester is a PEG linker containing a bromine and a hydrophilic PEG chain. The size and electronegative properties of bromine make it a good leaving group and able to participate in substitution reactions. The hydrophilic PEG linker increases the compound's solubility in aqueous media. | | Uses | Bromo-PEG5-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromo-PEG5-phosphonic acid ethyl ester Preparation Products And Raw materials |
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