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T&W GROUP |
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Bromo-PEG2-t-butyl ester manufacturers
- Br-PEG2-COOtBu
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2025-06-07
- CAS:1381861-91-1
- Min. Order: 25g
- Purity: >98.00%
- Supply Ability: 25g
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| | Bromo-PEG2-t-butyl ester Basic information |
| Product Name: | Bromo-PEG2-t-butyl ester | | Synonyms: | Bromo-PEG2-t-butyl ester;Bromo-PEG3-t-butyl ester;Br-PEG2-t-butyl ester;Br-PEG2-COOtBu;CAS_1381861-91-1;Bromo-PEG2-C2-Boc;Propanoic acid, 3-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester;Br-PEG2-CH2CH2COOtBu/Propanoic acid, 3-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester | | CAS: | 1381861-91-1 | | MF: | C11H21BrO4 | | MW: | 297.19 | | EINECS: | | | Product Categories: | | | Mol File: | 1381861-91-1.mol |  |
| | Bromo-PEG2-t-butyl ester Chemical Properties |
| Boiling point | 332.0±22.0 °C(Predicted) | | density | 1.240±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Liquid | | color | Colorless to light yellow | | InChI | InChI=1S/C11H21BrO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9H2,1-3H3 | | InChIKey | UOYAYHGUAATLSG-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCOCCOCCBr |
| | Bromo-PEG2-t-butyl ester Usage And Synthesis |
| Description | Bromo-PEG2-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromo-PEG2-t-butyl ester Preparation Products And Raw materials |
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