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N-(m-PEG4)-N'-(PEG2-acid)-Cy5

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N-(m-PEG4)-N'-(PEG2-acid)-Cy5 Basic information
Product Name:N-(m-PEG4)-N'-(PEG2-acid)-Cy5
Synonyms:N-(m-PEG4)-N'-(PEG2-acid)-Cy5
CAS:2107273-24-3
MF:C41H57ClN2O8
MW:741.36
EINECS:
Product Categories:
Mol File:2107273-24-3.mol
N-(m-PEG4)-N'-(PEG2-acid)-Cy5 Structure
N-(m-PEG4)-N'-(PEG2-acid)-Cy5 Chemical Properties
solubility Soluble in Water, DMSO, DMF, DCM
Safety Information
MSDS Information
N-(m-PEG4)-N'-(PEG2-acid)-Cy5 Usage And Synthesis
DescriptionN-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media.
UsesN-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(m-PEG4)-N'-(PEG2-acid)-Cy5 Preparation Products And Raw materials
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