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| | D-2-Aminobutyric acid Basic information |
| | D-2-Aminobutyric acid Chemical Properties |
| Melting point | >300 °C (lit.) | | alpha | -21.2 º (c=2, 6N HCl) | | Boiling point | 215.2±23.0 °C(Predicted) | | density | 1.2300 (estimate) | | refractive index | 1.4650 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble | | form | Crystalline Powder | | pka | 2.34±0.10(Predicted) | | color | White | | Optical Rotation | [α]20/D 21 to 19°, c = 4 in H2O | | Water Solubility | soluble | | BRN | 1720934 | | Major Application | peptide synthesis | | InChI | 1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 | | InChIKey | QWCKQJZIFLGMSD-GSVOUGTGSA-N | | SMILES | CC[C@@H](N)C(O)=O | | LogP | -0.064 (est) | | CAS DataBase Reference | 2623-91-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids |
| | D-2-Aminobutyric acid Usage And Synthesis |
| Chemical Properties | WHITE CRYSTALLINE POWDER | | Uses | (R)-2-Aminobutyric Acid is an isomer of L-Aminobutyric Acid (A602930) which is a receptor antagonist. | | Definition | ChEBI: D-alpha-aminobutyric acid is an optically active form of alpha-aminobutyric acid having D-configuration. It is an alpha-aminobutyric acid and a D-alpha-amino acid. It is an enantiomer of a L-alpha-aminobutyric acid. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | Currently, the methods reported in the literature for the synthesis of D-2-aminobutyric acid such as the synthesis of D-2-aminobutyric acid from D-configuration methionine by desulfurization and other steps; ammonification and hydrolysis reaction method of butyronic acid, and chemical disassembly method. First, the racemic 2-aminobutyric acid is acetylated to obtain N-acetyl-2-aminobutyric acid, and then the aminoacylase extracted from pig kidney is used to selectively hydrolyze off the (S)-configuration N-acetyl-2-aminobutyric acid to obtain the (S)-2-aminobutyric acid, and the (R)-N-acetyl-2-aminobutyric acid which is not hydrolyzed is subjected to the racemic treatment by an appropriate method to obtain racemic 2-aminobutyric acid, thus realizing the dynamic of its 2-aminobutanoic acid. Aminobutyric acid, thus realizing its dynamic kinetic splitting and achieving a final yield of 71.9%.
| | IC 50 | Microbial Metabolite; Human Endogenous Metabolite |
| | D-2-Aminobutyric acid Preparation Products And Raw materials |
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