t-Boc-Aminooxy-PEG3-oxyamine manufacturers
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| | t-Boc-Aminooxy-PEG3-oxyamine Basic information |
| Product Name: | t-Boc-Aminooxy-PEG3-oxyamine | | Synonyms: | t-Boc-Aminooxy-PEG3-oxyamine;tert-butyl (2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethoxy)carbamate;Boc-Aminooxy-PEG4-NH2;3,6,9,12-Tetraoxa-2-azatetradecanoic acid, 14-(aminooxy)-, 1,1-dimethylethyl ester;t-Boc-Aminooxy-PEG3-oxyamine boc | | CAS: | 2062663-66-3 | | MF: | C13H28N2O7 | | MW: | 324.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2062663-66-3.mol |  |
| | t-Boc-Aminooxy-PEG3-oxyamine Chemical Properties |
| density | 1.114±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, sealed storage, away from moisture | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.21±0.70(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | t-Boc-Aminooxy-PEG3-oxyamine Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG3-oxyamine is a PEG crosslinker with a t-Boc protected aminooxy and a free aminooxy group. The terminal oxyamine group can react with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. t-Boc can be removed under mild acidic conditions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-Aminooxy-PEG3-oxyamine Preparation Products And Raw materials |
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