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| | Boc-Aminooxy-PEG3-acid Basic information |
| Product Name: | Boc-Aminooxy-PEG3-acid | | Synonyms: | Boc-Aminooxy-PEG3-acid;t-Boc-Aminooxy-PEG3-acid;N-Boc-Aminooxy-PEG3-acid;3,6,9,12-Tetraoxa-2-azapentadecanedioic acid, 1-(1,1-dimethylethyl) ester;1-{[(tert-butoxy)carbonyl]amino}-1,4,7,10-tetraoxatridecan-13-oic acid;t-Boc-Aminooxy-PEG3-acid t-Boc-;BocHNO-PEG3-CH2CH2COOH;2,2-Dimethyl-4-oxo-3,6,9,12,15-pentaoxa-5-azaoctadecan-18-oic acid | | CAS: | 1835759-82-4 | | MF: | C14H27NO8 | | MW: | 337.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-82-4.mol |  |
| | Boc-Aminooxy-PEG3-acid Chemical Properties |
| density | 1.155±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DMF, DCM | | pka | 4.28±0.10(Predicted) |
| | Boc-Aminooxy-PEG3-acid Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG3-acid is a PEG linker containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. | | Uses | Boc-Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Boc-Aminooxy-PEG3-acid Preparation Products And Raw materials |
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