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| | t-Boc-Aminooxy-PEG4-CH2CO2H Basic information |
| Product Name: | t-Boc-Aminooxy-PEG4-CH2CO2H | | Synonyms: | t-Boc-Aminooxy-PEG4-CH2CO2H;3,6,9,12,15-Pentaoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) ester;t-Boc-Aminooxy-PEG4-CH2CO2H boc;N-Boc-Aminooxy-PEG4-CH2COOH;t-Boc-Aminooxy-PEG4-CH2COOH | | CAS: | 2028281-90-3 | | MF: | C15H29NO9 | | MW: | 367.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2028281-90-3.mol |  |
| | t-Boc-Aminooxy-PEG4-CH2CO2H Chemical Properties |
| density | 1.166±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) |
| | t-Boc-Aminooxy-PEG4-CH2CO2H Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG4-CH2CO2H is a crosslinking reagent with a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU). The Boc-protected amine can be deprotected under mild acidic conditions. PEG4 spacer increases solubility in aqueous media. | | Uses | Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether; PEGs | | References | [1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
| | t-Boc-Aminooxy-PEG4-CH2CO2H Preparation Products And Raw materials |
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