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BOC Sciences |
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1-631-485-4226; 16314854226 |
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| | MELK-T1(JNJ-47117096) Basic information |
| Product Name: | MELK-T1(JNJ-47117096) | | Synonyms: | MELK-T1(JNJ-47117096);MELK-T1;2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide;Benzamide, 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-;JNJ-47117096 | | CAS: | 1610586-62-3 | | MF: | C21H22N4O2 | | MW: | 362.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1610586-62-3.mol |  |
| | MELK-T1(JNJ-47117096) Chemical Properties |
| Boiling point | 558.8±50.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | pka | 13.13±0.50(Predicted) |
| | MELK-T1(JNJ-47117096) Usage And Synthesis |
| Uses | JNJ-47117096 is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM[1]. | | References | [1] Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. DOI:10.1021/ml5001245
[2] Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35(6). pii: e00267. DOI:10.1042/BSR20150194 |
| | MELK-T1(JNJ-47117096) Preparation Products And Raw materials |
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