jnj39758979 manufacturers
- JNJ-39758979
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- $59.00
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2026-09-10
- CAS:1046447-90-8
- Purity: 98.33%
- Supply Ability: 10g
- JNJ-39758979
-
- $59.00
-
2026-08-08
- CAS:1046447-90-8
- Purity: 98.33%
- Supply Ability: 10g
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| | jnj39758979 Basic information |
| Product Name: | jnj39758979 | | Synonyms: | jnj39758979;4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE;JNJ 39758979
(JNJ-39758979;2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-;(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine;agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979;JNJ-39758979, 10 mM in DMSO | | CAS: | 1046447-90-8 | | MF: | C11H19N5 | | MW: | 221.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1046447-90-8.mol |  |
| | jnj39758979 Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) | | form | Solid | | color | Pale Beige to Light Beige |
| | jnj39758979 Usage And Synthesis |
| Uses | JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM. | | in vivo | JNJ-39758979 (10 mg/kg; p.o.) treatment shows that the Cmax, t1/2 and F values are 0.3 μM, 7.5 hours, and 36%, respectively[1].
JNJ-39758979 (2 mg/kg; i.v.) treatment shows that the Vss, AUC, CL and t1/2 were 19.9 L/kg, 1.4 μM*h, 2.2 L/h, and 2.1 hours, respectively [1]. | Animal Model: | Sprague-Dawley rats[1] | | Dosage: | 10 mg/kg | | Administration: | Oral administration (Pharmacokinetic Analysis) | | Result: | The Cmax, t1/2 and F values were 0.3 μM, 7.5 hours, and 36%, respectively.
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| | IC 50 | Human H4 Receptor: 12.5 nM (Ki); Mouse H4 Receptor: 5.3 nM (Ki); Monkey H4 receptor: 25 nM (Ki); Rat H4 receptor: 188 nM (Ki); Guinea pig H4 receptor: 306 nM (Ki) |
| | jnj39758979 Preparation Products And Raw materials |
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