- Bergamotine
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2023-02-24
- CAS:7380-40-7
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Bergamotine
-
- $1.00
-
2019-07-06
- CAS:7380-40-7
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| | Bergamotine Basic information |
| | Bergamotine Chemical Properties |
| Melting point | 75-80 °C | | Boiling point | 503.7±50.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Pale Yellow | | BRN | 1353914 | | Major Application | food and beverages | | InChI | 1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+ | | InChIKey | DBMJZOMNXBSRED-OQLLNIDSSA-N | | SMILES | C\C(C)=C\CC\C(C)=C\COc1c2C=CC(=O)Oc2cc3occc13 | | LogP | 5.382 (est) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-23 | | Storage Class | 11 - Combustible Solids |
| | Bergamotine Usage And Synthesis |
| Chemical Properties | White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., with the highest content coming from lemon pulp, including Northern Adenophora and Notopterygium wilfordii. | | Uses | Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction. | | Definition | ChEBI: A natural product found in Citrus hystrix. | | in vivo | The anticancer efficacy of Bergamottin under in vivo conditions using female BALB/c nude mice (a total of 20 mice are used) is determined. Tumors are induced in the mice by injecting non-small cell lung cancer A549 cells (1×106 cells/mouse). After tumor formation, the mice are sacrificed and tumors are removed and their weights and volumes are calculated. The results show that 25, 50 and 100 mg/kg Bergamottin injection reduce the tumor weight from 1.61 g in the PBS-treated group (control) to 1.21, 0.42 and 0.15 g, respectively. Tumor weight in the nude mice is reduced much more significantly in the highest-concentration Bergamottin group (100 mg/kg body weight) compared with the vehicle group (P<0.05). Likewise, 25, 50 and 100 mg/kg Bergamottin injection reduces the tumor volume from 2.2 cm3 in the PBS-treated group (control) to 1.71, 1.1 and 0.51 cm3, respectively. The periodic measurement of the tumor xenograft volume indicates that the tumor volume in the nude mice is reduced considerably in the highest-concentration Bergamottin group (100 mg/kg body weight) compared with the vehicle group (P<0.05)[2]. | | IC 50 | CYP1A1: 10.703 nM (Ki); CYP1A1: 0.192 μM (IC50); CYP1A2: 5.077 μM (IC50); CYP2B2: 4.535 μM (IC50); CYP2B1: 9.495 μM (IC50) |
| | Bergamotine Preparation Products And Raw materials |
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