- DL-Nipecotic acid
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2026-06-30
- CAS:498-95-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kgs
- Nipecotic acid
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- $10.00
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2026-03-20
- CAS:498-95-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Nipecotic acid
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- $1.10
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2025-11-18
- CAS:498-95-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | DL-Nipecotic acid Basic information |
| | DL-Nipecotic acid Chemical Properties |
| Melting point | 261 °C (dec.) (lit.) | | Boiling point | 239.22°C (rough estimate) | | density | 1.1426 (rough estimate) | | refractive index | 1.4587 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | water: soluble50mg/mL, clear, colorless to faintly yellow | | form | Solid | | pka | pK1:3.35(+1);pK2:10.64(0) (25°C) | | color | White | | Water Solubility | Soluble in water | | Merck | 14,6560 | | BRN | 81096 | | InChI | InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9) | | InChIKey | XJLSEXAGTJCILF-UHFFFAOYSA-N | | SMILES | N1CCCC(C(O)=O)C1 | | CAS DataBase Reference | 498-95-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | TM6125380 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | DL-Nipecotic acid Usage And Synthesis |
| Chemical Properties | off-white to pale yellow-beige powder | | Uses | (+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis. | | Definition | ChEBI: A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 28, p. 602, 1963 DOI: 10.1021/jo01037a531 | | General Description | R()-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy. | | Synthesis | The general procedure for the synthesis of 3-piperidinecarboxylic acid from methyl nicotinate was as follows: 0.25 g of methyl nicotinate with HRO/Na-β catalyst (50 mg) in 40 mL of deionized water was added to the reactor. Subsequently, the reactor was subjected to hydrogen pressure of 15 bar and heated at 120 °C for 1 h of reaction. Upon completion of the reaction, the catalyst was separated by centrifugation and the resulting mixture of clarified products was analyzed using GC-MS. The reaction achieved 100% conversion of methyl nicotinate and gave 3-piperidinecarboxylic acid in 100% yield. | | References | [1] Patent: WO2017/60922, 2017, A1. Location in patent: Page/Page column 15; 22 |
| | DL-Nipecotic acid Preparation Products And Raw materials |
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