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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE

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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Suppliers list
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:Remacemide hydrochloride
CAS:111686-79-4
Package:10 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aromsyn Co., Ltd.
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Products Intro: Product Name:2-Amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride
CAS:111686-79-4
Purity:NLT 95% Package:1G;1KG;100KG Remarks:AS103835
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
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Products Intro: Product Name:Remacemide hydrochloride
CAS:111686-79-4
Purity:95% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
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Products Intro: Product Name:Remacemide hydrochloride
CAS:111686-79-4
Purity:>=99%(HPLC) Package:$133.9/10mg;$562.9/50mg;Bulk package Remarks:99%(HPLC)
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:Remacemide hydrochloride
CAS:111686-79-4
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE manufacturers
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Basic information
Product Name:2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
Synonyms:REMACEMIDE HYDROCHLORIDE;2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE;RemacemideHCl;2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride;2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid;2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-;fpl12924aa;pr934-423a
CAS:111686-79-4
MF:C17H21ClN2O
MW:304.82
EINECS:
Product Categories:
Mol File:111686-79-4.mol
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Structure
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Chemical Properties
Melting point 253-254°
storage temp. room temp
solubility H2O: >10mg/mL
form powder
color white to beige
Water Solubility Soluble to 100 mM in water
InChI1S/C17H20N2O.ClH/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14;/h2-11H,12-13,18H2,1H3,(H,19,20);1H
InChIKeyHYQMIUSWZXGTCC-UHFFFAOYSA-N
SMILESCl.CC(Cc1ccccc1)(NC(=O)CN)c2ccccc2
Safety Information
Hazard Codes Xn,N
Risk Statements 22-41-50/53
Safety Statements 26-39-45-60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS AB4349500
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Aquatic Acute 1
Eye Dam. 1
ToxicityLD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)
MSDS Information
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Usage And Synthesis
UsesAnticonvulsant (neuroprotective).
Biological ActivityNon-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).
Biochem/physiol ActionsRemacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels.
in vivo

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].

Animal Model:Female Sprague–Dawley rats ( 190-210 g )[3]
Dosage:100 mg/kg and 150 mg/kg
Administration:Orogastric gavage; once a day; 7 days
Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Tag:2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE(111686-79-4) Related Product Information
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