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| | (R)-(-)-1-Amino-2-propanol Basic information |
| | (R)-(-)-1-Amino-2-propanol Chemical Properties |
| Melting point | 24-26 °C (lit.) | | alpha | -18 º (c=1.8, H2O) | | Boiling point | 160 °C (lit.) | | density | 0.954 g/mL at 25 °C (lit.) | | vapor density | 2.6 (vs air) | | vapor pressure | <1 mm Hg ( 20 °C) | | refractive index | n20/D 1.4482(lit.) | | Fp | 165 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 12.92±0.35(Predicted) | | form | Liquid After Melting | | color | Clear colorless to light yellow | | Specific Gravity | 0.954 | | Optical Rotation | [α]20/D 23.5°, c = 1 in methanol | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 1718869 | | InChI | 1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m1/s1 | | InChIKey | HXKKHQJGJAFBHI-GSVOUGTGSA-N | | SMILES | C[C@@H](O)CN | | LogP | -1.127 (est) | | CAS DataBase Reference | 2799-16-8(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Propanol, 1-amino-, (R)-(2799-16-8) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 23-26-36-45 | | RIDADR | UN 3259 8/PG 2 | | WGK Germany | 1 | | RTECS | UA5775000 | | F | 10-34 | | Autoignition Temperature | 635 °F | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | (R)-(-)-1-Amino-2-propanol Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | (R)-(-)-1-Amino-2-propanol is a useful research intermediate used in the synthesis of other bioactive small molecules with pharmaceutical applications. | | Definition | ChEBI: A 1-aminopropan-2-ol that has R-configuration. | | Synthesis | GENERAL STEPS: Example 2 Synthesis of (R)-1-amino-2-propanol. To a 500 mL reaction vessel was added L-threonine (10 g, 0.839 mol), 2-cyclohexen-1-one (8.07 g, 0.084 mol) and polyethylene glycol. The mixture was stirred under a nitrogen atmosphere at 150-160 °C. After 72 h, the reaction was judged complete when the crystals were completely dissolved and the mixture appeared homogeneous. The yield of (R)-1-amino-2-propanol was confirmed to be 80.6% by gas chromatographic analysis. Subsequently, the reaction solution was distilled under reduced pressure at the same temperature and the fractions were collected at 54-62 °C (1-20 hPa) to give (R)-1-amino-2-propanol (44.4 g, yield: 70.4%, chemical purity: 99.0%, optical purity: 99.9% ee). | | References | [1] Chemistry Letters, 1986, p. 893 - 896
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1381 - 1387
[3] Patent: US2005/222430, 2005, A1. Location in patent: Page/Page column 2
[4] Synthetic Communications, 1993, vol. 23, # 8, p. 1071 - 1074 |
| | (R)-(-)-1-Amino-2-propanol Preparation Products And Raw materials |
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