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p-Toluenesulfonyl fluoride

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p-Toluenesulfonyl fluoride manufacturers

p-Toluenesulfonyl fluoride Basic information
Product Name:p-Toluenesulfonyl fluoride
Synonyms:4-TOLUENESULPHONYL FLUORIDE;4-TOLUENESULFONYL FLUORIDE;P-TOLUENESULPHONYL FLUORIDE;TOSYL FLUORIDE;4-methyl-benzenesulfonylfluorid;p-Fluorosulfonyltoluene;Tosyl fluoride, 4-Methylbenzenesulphonyl fluoride;p-Toluenesulfonyl fluoride, 97% 5GR
CAS:455-16-3
MF:C7H7FO2S
MW:174.19
EINECS:207-238-6
Product Categories:Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
Mol File:455-16-3.mol
p-Toluenesulfonyl fluoride Structure
p-Toluenesulfonyl fluoride Chemical Properties
Melting point 41-42 °C(lit.)
Boiling point 112 °C16 mm Hg(lit.)
density 1.2768 (estimate)
Fp 222 °F
storage temp. Storage temp. 2-8°C
form solid
AppearanceWhite to off-white Solid
Water Solubility Hydrolyzes in water.
Sensitive Moisture Sensitive
BRN 2208423
Exposure limitsACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3
CAS DataBase Reference455-16-3(CAS DataBase Reference)
EPA Substance Registry SystemBenzenesulfonyl fluoride, 4-methyl- (455-16-3)
Safety Information
Hazard Codes C
Risk Statements 20/21/22-34
Safety Statements 22-26-27-36/37/39-45
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS XT8050000
Hazard Note Corrosive
TSCA TSCA listed
HazardClass 8
PackingGroup II
HS Code 29049095
Toxicityrat,LD50,intraperitoneal,200mg/kg (200mg/kg),Nature. Vol. 173, Pg. 33, 1954.
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
p-Toluenesulfonyl fluoride Usage And Synthesis
Chemical PropertiesWhite to beige fused mass
UsesProtease inhibitor.
Usesp-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimers disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.
General Descriptionp-Toluenesulfonyl fluoride is a peroxygen bleach activator and is also useful in the treatment of Alzheimer′s disease.
reaction suitabilityreaction type: click chemistry
p-Toluenesulfonyl fluoride Preparation Products And Raw materials
Tag:p-Toluenesulfonyl fluoride(455-16-3) Related Product Information
toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester p-Toluenesulfonic acid monohydrate p-Toluenesulfonic acid p-Toluenesulfinic acid Benzenesulfonyl fluoride 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Phenylmethylsulfonyl fluoride p-Toluenesulfonyl fluoride 5'-p-Fluorosulfonyl-benzoyladenosine hydrochloride Sulforhodamine B 5-acid fluoride 4-(Fluorosulfonyl)benzoic acid 4-(Fluorosulfonyl)benzoyl chloride 4-(Chloromethyl)benzenesulphonyl fluoride 2,4,6-Trimethylbenzenesulfonyl fluoride 4'-Methylbiphenyl-4-sulfonylfluoride 4-(2-Hydroxy-1,1-dimethyl-ethyl)-benzenesulfonyl fluoride 4-Fluorosulfonyl-3-methoxy-benzoic acid 8-Cyclopentyl-N3-[3-(4-(fluorosulfonyl)benzoyloxy)propyl]-N1-propylxanthine