| Company Name: |
InvivoChem Gold |
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13549236410 |
| Email: |
sales@invivochem.cn |
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| | RGX-104 free Acid Basic information |
| Product Name: | RGX-104 free Acid | | Synonyms: | RGX-104 free Acid;610318-54-2 (FREE FORM) 610318-03-1 (HCL);RGX-104 (free form);SB742881;Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-;RGX-104freeAcid/SB742881;Abequolixron (RGX-104);(R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid | | CAS: | 610318-54-2 | | MF: | C34H33ClF3NO3 | | MW: | 596.08 | | EINECS: | | | Product Categories: | | | Mol File: | 610318-54-2.mol |  |
| | RGX-104 free Acid Chemical Properties |
| Boiling point | 677.1±55.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO:100.0(Max Conc. mg/mL);167.76(Max Conc. mM) | | form | Solid | | pka | 4.19±0.10(Predicted) | | color | White to off-white | | InChIKey | ZLJZDYOBXVOTSA-XMMPIXPASA-N | | SMILES | C1(CC(O)=O)=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C2=CC=CC=C2)C2=CC=CC=C2)C)=C1 |
| | RGX-104 free Acid Usage And Synthesis |
| Uses | RGX-104 is combination of a liver X receptor β agonist and GITR modulator for treatment of cancer.Liver X receptor beta agonist. | | in vivo | Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1]. | Animal Model: | NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1]. | | Dosage: | 100 mg/kg. | | Administration: | Oral administration daily for about 60 days. | | Result: | Robustly suppressed tumor growth and progression. |
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| | RGX-104 free Acid Preparation Products And Raw materials |
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