Coralyne chloride hydrate, 98+% manufacturers
- Coralyne chloride
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- $72.00
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2026-07-17
- CAS:38989-38-7
- Purity: 99.35%
- Supply Ability: 10g
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| | Coralyne chloride hydrate, 98+% Basic information |
| Product Name: | Coralyne chloride hydrate, 98+% | | Synonyms: | 8-methyl-2,3,10,11-tetramethoxydibenzo(a,g)quinoliziniumchloride;g)quinolizinium,8-methyl-2,3,10,11-tetramethoxy-dibenzo(chloride;nsc96349;coralyne chloride crystalline;2,3,10,11-tetramethoxy-8-methyldibenzo[a,g]quinolizinium chloride;(-)-Coralyne chloride hydrate;cancer,Topoisomerase,inhibit,neurodrug,Inhibitor,Coralyne,Coralyne chloride,Antileukemic,protoberberine,topoisomerase I;(-)-Coralyn chloride | | CAS: | 38989-38-7 | | MF: | C22H22ClNO4 | | MW: | 399.86738 | | EINECS: | 254-239-2 | | Product Categories: | Alkaloids | | Mol File: | 38989-38-7.mol |  |
| | Coralyne chloride hydrate, 98+% Chemical Properties |
| Melting point | 215°C | | storage temp. | 2-8°C | | solubility | DMSO:5.0(Max Conc. mg/mL);12.5(Max Conc. mM)
Water:5.0(Max Conc. mg/mL);12.5(Max Conc. mM) | | form | Solid | | color | Light yellow to yellow |
| | Coralyne chloride hydrate, 98+% Usage And Synthesis |
| Chemical Properties | orange crystalline powder | | Uses | Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparingcoralyne derivativesas DNA binding fluorescent probes[3]. | | IC 50 | Topoisomerase I | | References | [1] Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. DOI:10.1016/j.biopha.2017.04.027
[2] D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. DOI:10.1016/0968-0896(96)00054-5
[3] P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. DOI:10.1039/c6ra27684a |
| | Coralyne chloride hydrate, 98+% Preparation Products And Raw materials |
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