Coralyne chloride NEW
| Price | $72 | $128 | $289 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-22 |
Product Details
| Product Name: Coralyne chloride | CAS No.: 38989-38-7 |
| Purity: 99.35% | Supply Ability: 10g |
| Release date: 2025/10/22 |
Product Introduction
Bioactivity
| Name | Coralyne chloride |
| Description | Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA cleavage. |
| In vitro | There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1.5 mg/mL (3.75 mM), Sonication is recommended. H2O : 3 mg/mL (7.5 mM), Sonication is recommended. |
| Keywords | topoisomerase I | Topoisomerase | protoberberine | neurodrug | Inhibitor | inhibit | Coralyne Chloride | Coralyne chloride | Coralyne | cancer | Antileukemic |
| Inhibitors Related | Berberine chloride | EIDD-1931 | Flumequine | Levofloxacin hydrochloride | Norfloxacin | Prulifloxacin | Enoxacin | Pefloxacin Mesylate | Ciprofloxacin | Ciprofloxacin monohydrochloride | Etoposide | Cholesteryl Hemisuccinate |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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