(S)-BAY-293

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(S)-BAY-293 Suppliers list
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840
Email: psaitong@jm-bio.com
Company Name: SINO High Goal Chemical Technology Co., Ltd.  
Tel: 021-57646680 18306277365
Email: guoxin@chembiobanksh.com
Company Name: Beijing Biocreative Technology Co., Ltd.  
Tel: 15522676233
Email: 3007606172@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
(S)-BAY-293 Basic information
Product Name:(S)-BAY-293
Synonyms:(S)-BAY-293;BAY 293 Negative Control;4-Quinazolinamine, 6,7-dimethoxy-2-methyl-N-[(1S)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-;BAY 294
CAS:2244904-69-4
MF:C25H28N4O2S
MW:448.58
EINECS:
Product Categories:
Mol File:2244904-69-4.mol
(S)-BAY-293 Structure
(S)-BAY-293 Chemical Properties
Boiling point 553.4±50.0 °C(Predicted)
density 1.218±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka9.61±0.10(Predicted)
form Solid
color White to off-white
Optical Rotation[α]/D +86.0 to +106.0°, c =1.0 in DMSO
InChIKeyWEGLOYDTDILXDA-HNNXBMFYSA-N
SMILESC[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(S)-BAY-293 Usage And Synthesis
Uses(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor[1].
Biological ActivityBAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1c at & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1c at & 50 nM wt hKRAS).
storageStore at -20°C
References[1] Hillig RC, et, al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. DOI:10.1073/pnas.1812963116
(S)-BAY-293 Preparation Products And Raw materials
Tag:(S)-BAY-293(2244904-69-4) Related Product Information
BAY-293 (S)-BAY-293 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- 2,7-Diazaspiro[4.4]nonane-2-acetamide, α-cyclopentyl-7-[[(2R,3R)-3-cyclopropyl-1-methyl-2-aziridinyl]carbonyl]-N-[(1R,10S,12S,18S)-1-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-2,7,8,10,11,12,13,16,17,18,19,21,22,23-tetradecahydro-22,22-dimethyl-13,19-dioxo-2-(2,2,2-trifluoroethyl)-15H-3,5-etheno-14,18-imino-6,10-methano-6H-pyrrolo[3,4-g][1,12,4,18]dioxadiazacyclodocosin-12-yl]-, (αS,5S)- Y-27632 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-