| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
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| | Citric acid-1,5-13C2 Basic information |
| Product Name: | Citric acid-1,5-13C2 | | Synonyms: | CITRIC-1,5-13C2 ACID, 99 ATOM % 13C;CITRIC ACID (1,5-13C2, 98%);Citric acid-1,5-13C2 98 atom % 13C;Citric acid-1,5-13C?;1,5-13C2]-Citric acid;Citric acid-1,5-13C2;Citric acid (1,5-13C?, 98%);Citric acid-1,5-13C2 | | CAS: | 302912-06-7 | | MF: | C6H8O7 | | MW: | 194.1 | | EINECS: | | | Product Categories: | Alphabetical Listings;CStable Isotopes;Metabolic Research;Other;Stable Isotopes | | Mol File: | 302912-06-7.mol |  |
| | Citric acid-1,5-13C2 Chemical Properties |
| Melting point | 153-159 °C (lit.) | | form | solid | | InChI | 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/i3+1,4+1 | | InChIKey | KRKNYBCHXYNGOX-CQDYUVAPSA-N | | SMILES | OC(=O)C(O)(C[13C](O)=O)C[13C](O)=O | | CAS Number Unlabeled | 77-92-9 |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-36-39 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
STOT SE 3 |
| | Citric acid-1,5-13C2 Usage And Synthesis |
| Uses | Citric acid-13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. DOI:10.1007/s10616-013-9567-1
[3] Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan90(1):38-44. DOI:10.3109/10520295.2014.937745
[4] Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct33(10):4411-20. PMID:24123010 |
| | Citric acid-1,5-13C2 Preparation Products And Raw materials |
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