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E3 ligase Ligand 10 manufacturers
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| | E3 ligase Ligand 10 Basic information |
| Product Name: | E3 ligase Ligand 10 | | Synonyms: | E3 ligase Ligand 10;(S)-2-((S)-1-((S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoic acid;L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-;(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3,3-diphenylpropanoic acid | | CAS: | 1073560-68-5 | | MF: | C47H52N4O7 | | MW: | 784.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1073560-68-5.mol |  |
| | E3 ligase Ligand 10 Chemical Properties |
| Boiling point | 995.9±65.0 °C(Predicted) | | density | 1.256±0.06 g/cm3(Predicted) | | pka | 3.36±0.10(Predicted) |
| | E3 ligase Ligand 10 Usage And Synthesis |
| Uses | E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | | IC 50 | IAP | | References | [1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
| | E3 ligase Ligand 10 Preparation Products And Raw materials |
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