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| | E3 ligase Ligand 18 Basic information |
| Product Name: | E3 ligase Ligand 18 | | Synonyms: | E3 ligase Ligand 18;L-Cysteine, N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-;(2R)-3-({2-amino-9-[(4-chlorophenyl)methyl]-6-oxo-6,9-dihydro-3H-purin-8-yl}sulfanyl)-2-acetamidopropanoic acid;(R)-2-Acetamido-3-((2-amino-9-(4-chlorobenzyl)-6-oxo-6,9-dihydro-3H-purin-8-yl)thio)propanoic acid | | CAS: | 2241669-88-3 | | MF: | C17H17ClN6O4S | | MW: | 436.87 | | EINECS: | | | Product Categories: | | | Mol File: | 2241669-88-3.mol |  |
| | E3 ligase Ligand 18 Chemical Properties |
| density | 1.68±0.1 g/cm3(Predicted) | | pka | 3.17±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | E3 ligase Ligand 18 Usage And Synthesis |
| Uses | E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | | IC 50 | Cereblon | | References | [1] Heterocyclic compound. WO2018143403A1. |
| | E3 ligase Ligand 18 Preparation Products And Raw materials |
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