rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

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rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Suppliers list
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
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rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine manufacturers
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Basic information
Product Name:rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
Synonyms:rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine;L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-;Ligands for E3 Ligase,E3 ligase Ligand 8,Inhibitor,inhibit,E3 ligase-recruiting Moiety,E-3 ligase Ligand 8;(S)-2-((2S,3R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid;(2S)-2-[(2S,3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
CAS:1225383-33-4
MF:C31H34N2O6
MW:530.61
EINECS:
Product Categories:
Mol File:1225383-33-4.mol
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Structure
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Chemical Properties
Boiling point 815.8±65.0 °C(Predicted)
density 1.252±0.06 g/cm3(Predicted)
pka3.37±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Usage And Synthesis
UsesE3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
IC 50IAP
References[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Preparation Products And Raw materials
Tag:rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine(1225383-33-4) Related Product Information
E3 ligase Ligand 18 E3 ligase Ligand 10 L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- E3 ligase Ligand 14 rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine E3 ligase Ligand 13