E3 ligase Ligand 14 manufacturers
|
| | E3 ligase Ligand 14 Basic information |
| Product Name: | E3 ligase Ligand 14 | | Synonyms: | E3 ligase Ligand 14;tert-Butyl ((S)-1-(((S)-1-Cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate;tert-butyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S,4S)-4-(3-hydroxyphenoxy)-2-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate;CST 530, Phenol | | CAS: | 2241489-43-8 | | MF: | C38H52N4O7 | | MW: | 676.84 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![E3 ligase Ligand 14 Structure]() |
| | E3 ligase Ligand 14 Chemical Properties |
| Boiling point | 899.5±65.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | pka | 9.55±0.10(Predicted) |
| | E3 ligase Ligand 14 Usage And Synthesis |
| Uses | E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | | IC 50 | IAP | | References | [1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
| | E3 ligase Ligand 14 Preparation Products And Raw materials |
|