Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- manufacturers
- NSC-140873
-
- $1980.00
-
2026-05-11
- CAS:106410-13-3
- Purity:
- Supply Ability: 10g
|
| | Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- Basic information |
| | Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- Chemical Properties |
| Melting point | 196-197 °C | | Boiling point | 569.8±50.0 °C(Predicted) | | density | 1.427±0.06 g/cm3(Predicted) | | pka | 12.41±0.70(Predicted) |
| | Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- Usage And Synthesis |
| Uses | NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2]. | | References | [1] Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.
[2] Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. DOI:10.1073/pnas.1200037109 |
| | Acetamide, 2-amino-N-[4-chloro-2-(1H-pyrrol-2-ylcarbonyl)phenyl]- Preparation Products And Raw materials |
|