Pomalidomide-6-2-2-6-N3

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Company Name: Alfa Chemistry
Tel: +1-5166625404;
Email: Info@alfa-chemistry.com
Products Intro: Product Name:Pomalidomid-C6-PEG3-butyl-N3
CAS:2300178-66-7
Company Name: Xian confluore Biological Technology Co., Ltd.
Tel: +86-15680926068
Email: 1924344760@confluore.cn
Products Intro: Product Name:Pomalidomide-6-2-2-6-N3
CAS:2300178-66-7
Purity:>95.00% Package:100mg
Company Name: Aladdin Scientific
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Products Intro: Product Name:Pomalidomide-C-PEG-butyl azide
CAS:2300178-66-7
Purity:>=95% Package:$1257.9/50mg;Bulk package Remarks:95%
Company Name: Xi'an Confluore Biological Technology Co., Ltd.  
Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Products Intro: Product Name:Pomalidomide-6-2-2-6-N3
CAS:2300178-66-7
Purity:95% HPLC Package:10MG;25MG;50MG;100MG;1G;5G
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:Pomalidomide-C6-PEG3-butyl azide
CAS:2300178-66-7
Purity:98% 纯度 Package:1克;5克;100克

Pomalidomide-6-2-2-6-N3 manufacturers
Pomalidomide-6-2-2-6-N3 Basic information
Product Name:Pomalidomide-6-2-2-6-N3
Synonyms:Pomalidomide-6-2-2-6-N3;Poma-6-2-2-6-N3;Pomalidomide-C?-PEG?-butyl azide;Pomalidomid-C6-PEG3-butyl-N3;Hexanamide, 6-[2-[2-[(6-azidohexyl)oxy]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;Pomalidomide-C6-PEG3-butyl azide
CAS:2300178-66-7
MF:C29H40N6O8
MW:600.67
EINECS:
Product Categories:
Mol File:2300178-66-7.mol
Pomalidomide-6-2-2-6-N3 Structure
Pomalidomide-6-2-2-6-N3 Chemical Properties
storage temp. 2-8°C
form powder or crystals
InChIKeyJUXLQOHNAZVQSN-UHFFFAOYSA-N
SMILESO=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCOCCOCCCCCCN=[N+]=[N-])=O)=O)NC1=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Pomalidomide-6-2-2-6-N3 Usage And Synthesis
UsesProtein degrader builiding block Pomalidomide-C6-PEG3-Butyl Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitabilityreaction type: click chemistry
reagent type: ligand-linker conjugate
Pomalidomide-6-2-2-6-N3 Preparation Products And Raw materials
Tag:Pomalidomide-6-2-2-6-N3(2300178-66-7) Related Product Information
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide 4'-alkylC5-acid E3 ligase Ligand-Linker Conjugates 49 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-