E3 ligase Ligand-Linker Conjugates 49

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E3 ligase Ligand-Linker Conjugates 49 Basic information
Product Name:E3 ligase Ligand-Linker Conjugates 49
Synonyms:Cereblon Ligand-Linker Conjugates 14;E3 ligase Ligand-Linker Conjugates 49;Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH;3,9,12,18-Tetraoxaeicosanoic acid, 20-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]amino]-20-oxo-;1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,12,15,21-tetraoxa-3-azatricosan-23-oic acid;1-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]-2,8,11,17-tetraoxanonadecan-19-oic acid;1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,12,15,21-tetraoxa-3-azatricosan-23-oic acid?, Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH;20-[[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]amino]-20-oxo-3,9,12,18-tetraoxaeicosanoic acid
CAS:2351103-63-2
MF:C31H44N4O11
MW:648.7
EINECS:
Product Categories:
Mol File:2351103-63-2.mol
E3 ligase Ligand-Linker Conjugates 49 Structure
E3 ligase Ligand-Linker Conjugates 49 Chemical Properties
Boiling point 900.2±65.0 °C(Predicted)
density 1.303±0.06 g/cm3(Predicted)
storage temp. 2-8°C, stored under nitrogen
pka3.52±0.10(Predicted)
form Oil
color Light brown to brown
Safety Information
MSDS Information
E3 ligase Ligand-Linker Conjugates 49 Usage And Synthesis
UsesPomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
IC 50Cereblon
References[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
E3 ligase Ligand-Linker Conjugates 49 Preparation Products And Raw materials
Tag:E3 ligase Ligand-Linker Conjugates 49(2351103-63-2) Related Product Information
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide 4'-alkylC5-acid Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-