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| | 5-(Ethylthio)-1H-tetrazole Basic information |
| | 5-(Ethylthio)-1H-tetrazole Chemical Properties |
| Melting point | 72-80 °C(lit.) | | Boiling point | 81-82 °C | | density | 0.786 g/mL at 25 °C | | Fp | 42 °F | | storage temp. | 2-8°C | | solubility | soluble, clear, colorless | | form | buffered aqueous solution | | pka | 3.89±0.10(Predicted) | | color | solid white | | biological source | rabbit | | InChI | InChI=1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7) | | InChIKey | GONFBOIJNUKKST-UHFFFAOYSA-N | | SMILES | N1=C(SCC)N=NN1 | | CAS DataBase Reference | 89797-68-2(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn,F | | Risk Statements | 36/37/38-44-36-20/21/22-11-5 | | Safety Statements | 26-35-36/37-16-36 | | RIDADR | UN 1648 3/PG 2 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 4.1 | | PackingGroup | III | | HS Code | 29299000 | | Storage Class | 4.1A - Other explosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B
STOT SE 3 |
| | 5-(Ethylthio)-1H-tetrazole Usage And Synthesis |
| Chemical Properties | White crystals | | Uses | - Solid-Phase Synthesis of Symmetrical Dinucleoside Phosphodiesters: Explores the efficiency of 5-(Ethylthio)-1H-tetrazole in the solid-phase synthesis of dinucleoside phosphodiesters, underlining its significance in the streamlined production of biologically relevant molecules (Ahmadibeni et al., 2007).
- Synthesis, Deprotection, Analysis, and Purification of RNA and Ribozymes: Utilizes 5-(Ethylthio)-1H-tetrazole in the synthesis and processing of RNA and ribozymes, highlighting its critical role in molecular biology and genetic engineering research (Wincott et al., 1995).
| | Preparation | 5-(Ethylthio)-1H-Tetrazole is prepared from the corresponding alkyl thiocyanate and sodium azide through a [2+3] cycloaddition under phase transfer catalytic conditions (eq 1). The ratio of the solvent (water to toluene) as well as the reaction temperature are important factors in obtaining preparative yields of the alkylthiotetrazoles. 5-Ethylthio-1H-tetrazole has also been prepared using DMF as solvent albeit in much lower yield.
 | | Application | 5-(Ethylthio)-1H-tetrazole is used a powerful activator in DNA and RNA syntheses. | | General Description | 5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis. | | Purification Methods | recrystallized from toluene. |
| | 5-(Ethylthio)-1H-tetrazole Preparation Products And Raw materials |
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