Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) manufacturers
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| | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Basic information |
| Product Name: | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) | | Synonyms: | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI);Pyrido[3.4-d]pyrimidin-4-ol;Pyrido[3,4-d]pyriMidin-4(3H)-one;3H-Pyrido[3,4-d]pyrimidin-4-one;3,4-Dihydropyrido[3,4-d]pyrimidin-4-one;3H,4H-Pyrido[3,4-d]pyrimidin-4-one;Pyrido[3,4-d]pyriMidin-4-one;Pyrido[3,4-d]pyrimidin-4(3H) | | CAS: | 19178-25-7 | | MF: | C7H5N3O | | MW: | 147.13 | | EINECS: | | | Product Categories: | PYRIMIDINE | | Mol File: | 19178-25-7.mol | ![Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Structure](CAS/GIF/19178-25-7.gif) |
| | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Chemical Properties |
| Melting point | 305℃ | | Boiling point | 346.2±34.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.95±0.20(Predicted) | | Appearance | Light brown to gray Solid |
| | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Usage And Synthesis |
| Synthesis | 3-Aminoisonicotinic acid (691 mg, 5.0 mmol), formamidine acetate (573 mg, 5.5 mmol) and anhydrous ethanol (10 mL) were added to a Biotage microwave reactor tube. The reaction mixture was placed in a microwave reactor and heated at 160 °C for 30 min. After completion of the reaction, the reaction solution was diluted with deionized water (20 mL) and cooled to 0 °C in an ice bath. The resulting suspension was extracted and the filter cake was washed with ice-cooled deionized water (10 mL) to afford quinazoline A2 (259 mg, 35% yield) in white solid form. The product was analyzed by LC-MS showing purity >98% (m/z = 148.0 [M + H]+, retention time Rt = 0.604 min). | | References | [1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[2] Patent: WO2014/179237, 2014, A1. Location in patent: Paragraph 00491 |
| | Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Preparation Products And Raw materials |
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