- VitaMin D4
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2026-06-30
- CAS:511-28-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- VITAMIN D3
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- $9.60
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2026-05-28
- CAS:511-28-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000kg
- VitaMin D4
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- $5.00
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2026-04-10
- CAS:511-28-4
- Min. Order: 1KG
- Purity: 99% hplc
- Supply Ability: 500TONS
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| Product Name: | VitaMin D4 | | Synonyms: | RACUMIN D;OLEOVITAMIN D3;ANTI-RACHITIC VITAMIN;CALCIOL;CHOLECALCIFEROLUM;22-Dihydroergocalciferol;Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,4S)-1,4,5-trimethylhexyl]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-;(3S,5Z,7E)-9,10-Secoergosta-5,7,10-trien-3-ol | | CAS: | 511-28-4 | | MF: | C28H46O | | MW: | 398.66 | | EINECS: | 208-127-5 | | Product Categories: | Steroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 511-28-4.mol |  |
| | VitaMin D4 Chemical Properties |
| Melting point | 83-86 °C(lit.) | | alpha | D18 +89.3° (c = 0.47 in acetone) | | Boiling point | 504.9±29.0 °C(Predicted) | | density | 0.96 | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform | | form | Powder | | pka | 14.74±0.20(Predicted) | | color | Off-white to light yellow | | Stability: | Hygroscopic, Temperature Sensitive | | InChIKey | DIPPFEXMRDPFBK-JPWDPSJFSA-N | | SMILES | [C@H]1(O)CCC(=C)/C(=C\C=C2/CCC[C@@]3(C)[C@@]/2([H])CC[C@@H]3[C@H](C)CC[C@H](C)C(C)C)/C1 | | CAS DataBase Reference | 511-28-4(CAS DataBase Reference) |
| Hazard Codes | T+ | | Risk Statements | 24/25-26-48/25 | | Safety Statements | 28-36/37 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 2 | | RTECS | VS2900000 | | F | 8-10-23 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 3 Dermal
Acute Tox. 3 Oral
STOT RE 1 Oral |
| | VitaMin D4 Usage And Synthesis |
| Synthesis in Skin | Once vitamin D, enters the circulation, it is transported to the liver where it is hydroxylated to 25-hydroxyvitamin D3 (25-(OH)D3). 25-Hydroxyvitamin D3 is the major circulating form of vitamin D3 and its determination is often used to measure the vitamin D status of a patient. Although 1 ,25-(OH)2D3 has a marked effect on inhibiting proliferation of cultured human fibroblasts and keratinocytes and inducing terminal differentiation of cultured keratinocytes, there is no evidence that a deficiency in this hormone will increase proliferative activity in human skin. Thus, it would appear that 1,25-(OH)D3 is not a major regulator of dermal and epidermal proliferation and differentiation. Despite the fact that 1,25-(OH)2D3 is not a major participant in the regulation of epidermal differentiation, the observations that 1,25-(OH)D3 can inhibit the hyperproliferative activity of epidermal cells in patients with psoriasis is intriguing. It should be noted that patients with psoriasis have a normal metabolism of vitamin D to 25-hydroxyvitamin D and 1 ,25-(OH)2D3.24 Therefore, 1 ,25-(OH)2D3 and its analogs hold promise as unique pharmacologic agents for treating hyperproliFerative disorders of the skin such as psoriasis. | | Description | Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of
solar ultraviolet irradiation of 7-dehydrocholesterol in the skin.
In 1966, it was first recognized that vitamin
D must undergo activation via two oxidative metabolic steps. The first oxidation to
25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and
is catalyzed by vitamin D 25-hydroxylase. This activation step is not
regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also
is the primary storage form of vitamin D. | | Chemical Properties | Pale Yellow Oil | | Uses | Vitamin D4 is the active analogue of Vitamin D. | | Definition | ChEBI: Vitamin D4 is it is present in mushrooms. It has a role as a fungal metabolite. It is a vitamin D and a seco-ergostane. | | Biological Functions | Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D.
The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result
of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the
transport of calcium in each of the target tissues
Active vitamin D works in concert with PTH to enhance active
intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If
serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal
mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize
active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the
24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D. | | Source | Vitamin D is a 9,10-secosteroid and 6 forms have been identified. The importance of vitamin D in bone (calcium homeostasis) is well established, and vitamin D has been the subject of increased attention in recent years for its role in muscle function, immunology, heart and cardiovascular disease, cancer, and insulin secretion. The vitamin D4 precursor 22,23-dihydroergosterol was present in all mushroom composites. The levels were not correlated with vitamin D4, but differed among species. Enoki mushrooms had a notably higher 22,23-dihydroergosterol content, with an average of 16.5 mg/100g compared to 4.49–8.89 mg/ 100 g in other types of mushrooms. |
| | VitaMin D4 Preparation Products And Raw materials |
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