Methyl-4-amino-3-fluorobenzoate

Methyl-4-amino-3-fluorobenzoate Suppliers list

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

Company Name:	Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel:	+86-21-54098501
Email:	sales@sinch.com.cn

Methyl-4-amino-3-fluorobenzoate manufacturers

Methyl-4-amino-3-fluorobenzoate Basic information

Product Name:	Methyl-4-amino-3-fluorobenzoate
Synonyms:	Methyl-4-amino-3-fluorobenzoate;2-Fluoro-4-(methoxycarbonyl)aniline;Benzoic acid, 4-aMino-3-fluoro-, Methyl ester;Methyl 3-fluoro-4-aMinobenzoate;3-Fluoro-4-aminobenzoic acid methyl ester
CAS:	185629-32-7
MF:	C8H8FNO2
MW:	169.15
EINECS:
Product Categories:
Mol File:	Mol File

Methyl-4-amino-3-fluorobenzoate Chemical Properties

Melting point	109-110°C
Boiling point	296℃
density	1.264
Fp	133℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	powder
pka	1.07±0.10(Predicted)
color	White to off-white

Safety Information

MSDS Information

Methyl-4-amino-3-fluorobenzoate Usage And Synthesis

Uses	4-Amino-3-fluorophenylcarboxylic acid methyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate.
Chemical Properties	Brown solid
Synthesis	185629-31-6 185629-32-7 General procedure for the synthesis of methyl 4-amino-3-fluorobenzoate from methyl 3-fluoro-4-nitrobenzoate: Methyl 3-fluoro-4-nitrobenzoate (2.50 g, 12.5 mmol) and Pd/C catalyst (300 mg, 10 wt%) were placed in a 1:1 EtOAc/EtOH solvent mixture (40 mL). The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 16 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford methyl 4-amino-3-fluorobenzoate (2.1 g, 99% yield) as a beige solid. Mass spectrometry analysis (ES+): the theoretical molecular weight of C8H8FNO2 was 169 and the measured value was 170 [M + H]+.
References	[1] Patent: WO2018/81276, 2018, A1. Location in patent: Page/Page column 154 [2] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0096; 0097 [3] Patent: WO2007/16392, 2007, A2. Location in patent: Page/Page column 48 [4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359 [5] Patent: US2003/232889, 2003, A1. Location in patent: Page/Page column 15

Methyl-4-amino-3-fluorobenzoate Preparation Products And Raw materials

Raw materials	4-AMINO-3-FLUOROBENZOIC ACID-->3-Methoxy-4-nitrobenzoic acid-->3-Fluoro-4-nitrobenzoic acid-->METHYL 3,4-DIFLUOROBENZOATE-->METHYL 3-FLUORO-4-NITROBENZENECARBOXYLATE-->Palladium-->Ethanol-->Methanol-->Ethyl acetate-->Activated carbon
Preparation Products	3-Fluoro-4-(MethylsulfonaMido)benzoic Acid-->Methyl 4-(Chlorosulfonyl)-3-fluorobenzoate

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