| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
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| | KRP-203 Basic information |
| Product Name: | KRP-203 | | Synonyms: | 2-Amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol Hydrochloride;KRP-203;2-Amino-2-(2-(4-(3-benzyloxyphenylthio)-2-chlorophenyl)ethyl)-1,3-propanediol hydrochloride;KRP-203 (hydrochloride);2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chloro-phenethyl)propane-1,3-diol hydrochloride;KRP203/2-AMino-2-(2-(4-(3-benzyloxyphenylthio)-2-chlorophenyl)ethyl)-1,3-propanediol hydrochloride;2-Amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol;2-AMINO-2-[2-[2-CHLORO-4-[[3-(PHENYLMETHOXY)PHENYL]THIO]PHENYL]ETHYL]-1,3-PROPANEDIOL HCL | | CAS: | 509088-69-1 | | MF: | C24H27Cl2NO3S | | MW: | 480.45 | | EINECS: | 1312995-182-4 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Sulfur & Selenium Compounds | | Mol File: | 509088-69-1.mol |  |
| | KRP-203 Chemical Properties |
| Melting point | 199-200 ºC (DEC.) | | storage temp. | Refrigerator | | solubility | DMSO, Methanol | | form | Solid | | color | White to Off-White |
| | KRP-203 Usage And Synthesis |
| Uses | A novel immunomodulator | | Uses | A novel sphingosine-1-phosphate receptor agonists in the treatment of autoimmune diseases. Immunosuppressant. | | in vivo | Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R / Mice[1].
Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2].
| Animal Model: | Inbred male DA (MHC haplotype: RT1a) rats[2] | | Dosage: | 0.1 and 1 mg/kg | | Administration: | Orally; daily; for 100 days
| | Result: | Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.
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| | KRP-203 Preparation Products And Raw materials |
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