Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester Basic information
Product Name:Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester
Synonyms:Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester;Steroid sulfatase-IN-1
CAS:2403716-19-6
MF:C14H10Cl2N4O3S
MW:385.23
EINECS:
Product Categories:
Mol File:2403716-19-6.mol
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester Structure
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester Chemical Properties
Boiling point 623.5±65.0 °C(Predicted)
density 1+-.0.1 g/cm3(Predicted)
pka8.09±0.70(Predicted)
Safety Information
MSDS Information
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester Usage And Synthesis
UsesSteroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 nM. Steroid sulfatase-IN-1 shows antitumor activity in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].
in vivo

Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity in Breast Carcinoma Model[1].

Animal Model:67NR mouse (Breast Carcinoma Model)[1]
Dosage:50 mg/kg
Administration:P.o.
Result:Showed significant antitumor activity with the TGI value of 51%.
References[1] Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056. DOI:10.1021/acs.jmedchem.1c02220
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester Preparation Products And Raw materials
Tag:Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester(2403716-19-6) Related Product Information
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