1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE

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1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Basic information
Product Name:1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
Synonyms:1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;2-O-ETHYL-PAF;E-PAF;LPHUUVMLQFHHQG-AREMUKBSSA-N;2-O-ETHYL PAF C-16
CAS:78858-42-1
MF:C26H56NO6P
MW:509.7
EINECS:
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Mol File:78858-42-1.mol
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Structure
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Chemical Properties
solubility DMF: >125 μg/ml; DMSO: <20 μg/ml; Ethanol: >10 mg/ml; PBS pH 7.2: >11 mg/ml
form A lyophilized powder
Safety Information
MSDS Information
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Usage And Synthesis
Description2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP. 2-O-ethyl PAF C-16 causes aggregation of neutrophils in the presence of divalent cations and a desensitization to aggregation in the absence of divalent cations.
Uses2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM[1].
DefinitionChEBI: 2-O-ethyl PAF C-16 is a glycerophosphocholine and an ether lipid.
References[1] Aoki Y, et al. A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DOI:10.1016/0022-1759(95)00147-3
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Preparation Products And Raw materials
Tag:1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE(78858-42-1) Related Product Information
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