3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)-

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3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Basic information
Product Name:3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)-
Synonyms:3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)-
CAS:2857049-72-8
MF:C22H25ClF2N6O3
MW:494.92
EINECS:
Product Categories:
Mol File:2857049-72-8.mol
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Structure
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Chemical Properties
Boiling point 701.0±70.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
solubility DMSO: Soluble
pka14.85±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Usage And Synthesis
UsesTDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10)inhibitorwith slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC50 value of 5.5 nM[1].
References[1] Miller M, et al. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem. 2022 Nov 8. DOI:10.1021/acs.jmedchem.2c01133
[2] MELANIE BALBACH. On-demand male contraception via acute inhibition of soluble adenylyl cyclase.[J]. Nature Communications, 2023, 14 1: 637. DOI: 10.1038/s41467-023-36119-6
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- Preparation Products And Raw materials
Tag:3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)-(2857049-72-8) Related Product Information
ESI-08 H-8 dihydrochloride Adenosine 5'-methylenediphosphate (hydrate) Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- TDI-10229 2',5'-DIDEOXYADENOSINE