| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Ark Pharm, Inc. |
| Tel: |
847-367-3680 |
| Email: |
sales@arkpharminc.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | 2-Bromo-6-hydrazinylpyridine Basic information |
| Product Name: | 2-Bromo-6-hydrazinylpyridine | | Synonyms: | 2-Diazanyl-6-Bromo Pyridine;2-hydrazine-6-bromopyridine;2-(6-bromopyridin-2-yl)hydrazine;2-Bromo-6-hydrazinopydine;2-bromo-6-hydrazinopyridine(SALTDATA: HCl);2-Bromo-6-hydrazinopyridine 97+%;(6-Bromopyridin-2-yl)hydrazine;1-(6-bromopyridin-2-yl)hydrazine | | CAS: | 26944-71-8 | | MF: | C5H6BrN3 | | MW: | 188.03 | | EINECS: | | | Product Categories: | Pyridine;Heterocyclic Compounds | | Mol File: | 26944-71-8.mol |  |
| | 2-Bromo-6-hydrazinylpyridine Chemical Properties |
| Melting point | 117-118℃ | | Boiling point | 265.9±50.0 °C(Predicted) | | density | 1.82±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | soluble in Methanol | | form | Solid | | pka | 9.08±0.70(Predicted) | | color | Pale brown |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HazardClass | 6.1 | | HS Code | 2933399990 |
| | 2-Bromo-6-hydrazinylpyridine Usage And Synthesis |
| Uses | 2-Bromo-6-hydrazinylpyridine is used as an intermediate in organic synthesis for the production and research of other compounds. | | Synthesis | General procedure for the synthesis of 2-bromo-6-hydrazinopyridine from 2,6-dibromopyridine: commercially available 2,6-dibromopyridine (4.12 g, 16.6 mmol) was suspended in ethanol (40 mL), followed by the addition of hydrazine hydrate (10 mL, 97.6 mmol, 50-60% aqueous solution). The reaction mixture was heated and refluxed in a sand bath at 115°C for 18 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/n-heptane (60/40, v/v) to afford 2-bromo-6-hydrazinopyridine as an off-white solid (3.05 g, 93% yield).1H-NMR (400 MHz, CDCl3) δ: 7.33 (t, 1H), 6.83 (d, 1H ), 6.67 (d, 1H), 6.00 (br-s, 1H), 3.00-3.33 (br-s, 2H). | | References | [1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 29
[3] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 54
[4] Patent: WO2015/110263, 2015, A1. Location in patent: Page/Page column 159
[5] Patent: US2017/2005, 2017, A1. Location in patent: Paragraph 0760; 0761; 0762; 0763 |
| | 2-Bromo-6-hydrazinylpyridine Preparation Products And Raw materials |
|