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| | M40 (trifluoroacetate salt) Basic information |
| | M40 (trifluoroacetate salt) Chemical Properties |
| solubility | Water: Soluble |
| | M40 (trifluoroacetate salt) Usage And Synthesis |
| Description | M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).1,2 It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM).1 M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2 receptor (EC50 = 16.2 nM) and inhibits forskolin-induced cAMP accumulation in RIN-m5F pancreatic β-cells when used at concentrations of 10 or 100 nM.1,2 In vivo, M40 (9.36 nmol/animal, i.c.v.) reverses galanin-induced inhibition of scopolamine-induced hippocampal acetylcholine (ACh) release in conscious rats.2 M40 reduces galanin-induced increases in food intake in rats. It improves cardiac function and decreases cardiac fibrosis in a rat model of heart failure induced by sustained coronary artery ligation when administered at a dose of 30 nmol/kg.3 M40 (20 µg/animal) increases the intromission frequency and ejaculation latency in sexually sluggish male mice.4WARNING This product is not for human or veterinary use. | | References | [1] BETH BOROWSKY . Cloning and characterization of the human galanin GALR2 receptor[J]. Peptides, 1998, 19 10: Pages 1771-1781. DOI: 10.1016/s0196-9781(98)00133-8
[2] T BARTFAI. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 23: 11287-11291. DOI: 10.1073/pnas.90.23.11287
[3] AO CHEN. Effects of the Galanin Receptor Antagonist M40 on Cardiac Function and Remodeling in Rats with Heart Failure[J]. Cardiovascular Therapeutics, 2015, 33 5: 288-293. DOI: 10.1111/1755-5922.12144
[4] A. BENELLI. Pharmacological manipulation of brain galaninergic system and sexual behavior in male mice[J]. Psychopharmacology, 2002, 160 1: 325-330. DOI: 10.1007/s00213-001-0992-z |
| | M40 (trifluoroacetate salt) Preparation Products And Raw materials |
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