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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine >2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER

2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER

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Products Intro: Product Name:2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER
CAS:193537-14-3
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Products Intro: Product Name:2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER
CAS:193537-14-3
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Products Intro: Product Name:Ethyl 6-Boc-2-amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3-carboxylate
CAS:193537-14-3
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Products Intro: Product Name:2-Amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3,6-dicarboxylicacid6-tertbutylester3-ethylester
CAS:193537-14-3
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Products Intro: Product Name:2-amino-4,7-dihydro-5h-thieno(2,3-c)pyridine-3,6-dicarboxylic acid 6-tert-butyl 3-ethyl
CAS:193537-14-3
Purity:99% Package:1kg

2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER manufacturers
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER Basic information
Product Name:2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER
Synonyms:Ethyl2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate,N-BOCprotected95%;Ethyl 2-amino-6-Boc-4,7-dihydro-5H-thieno[2,3-c]pyridine-3-carboxylate;6-O-tert-butyl 3-O-ethyl 2-amino-5,7-dihydro-4H-thieno[2,3-c]pyridine-3,6-dicarboxylate;2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER;6-TERT-BUTYL 3-ETHYL-2-AMINO-4,5-DIHYDRO-THIENO[2,3-C]PYRIDINE-3,6(7H)-DICARBOXYLATE;6-(TERT-BUTYL) 3-ETHYL 2-AMINO-4,7-DIHYDROTHIENO[2,3-C]PYRIDINE-3,6(5H)-DICARBOXYLATE;BUTTPARK 75\08-01;Ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate, N-BOC protected
CAS:193537-14-3
MF:C15H22N2O4S
MW:326.41
EINECS:251-156-6
Product Categories:CHIRAL CHEMICALS;Esters;Fused Ring Systems
Mol File:193537-14-3.mol
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER Structure
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER Chemical Properties
Melting point 153 °C
Boiling point 492.5±45.0 °C(Predicted)
density 1.252±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka0.40±0.20(Predicted)
AppearanceLight yellow to yellow Solid
CAS DataBase Reference193537-14-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/39
Hazard Note Irritant
HS Code 2934999090
MSDS Information
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER Usage And Synthesis
Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3

Ethyl cyanoacetate

105-56-6

2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER

193537-14-3

General Steps: Step a. Synthesis of 2-amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3,6-dicarboxylic acid 6-tert-butyl 3-ethyl ester In anhydrous ethanol (50 mL), N-tert-butoxycarbonyl-4-piperidone (12.9 g), ethyl cyanoacetate (7.345 g), and sulfur powder (2.080 g) were mixed, followed by the addition of triethylamine (9 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the precipitate was collected by filtration and washed with ethanol to afford 2-amino-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylic acid-6-tert-butyl ester (18.7 g, 88% yield). Product characterization data: 1H NMR (300 MHz, CDCl3): δ 6.02 (s, 2H), 4.31 (s, 2H), 4.23 (q, 2H, J = 7.2 Hz), 3.58 (t, 2H, J = 6.0 Hz), 2.72-2.80 (br s, 2H), 1.44 (s, 9H), 1.30 (t, 3H, J = 7.2 Hz). LC-MS (ESI) m/z: 327.0 (M + H)+.

References[1] Synlett, 2010, # 9, p. 1351 - 1354
[2] Patent: US2010/120805, 2010, A1. Location in patent: Page/Page column 44
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 20, p. 7316 - 7326
[4] Patent: WO2009/33581, 2009, A1. Location in patent: Page/Page column 62
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3101 - 3112
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER Preparation Products And Raw materials
Raw materialsN-(tert-Butoxycarbonyl)-4-piperidone-->1-Boc-3-piperidone-->Ethyl cyanoacetate-->Triethylamine-->Ethanol-->Sulfur
Preparation ProductsBUTTPARK 77\08-25
Tag:2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER(193537-14-3) Related Product Information
Ethyl oxazole-4-carboxylate ethyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate ETHYL 2 3-BUTADIENOATE 95 Ethyl 2-(hydroxymethyl)acrylate ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate ETHYL 2,3-EPOXYPROPANOATE ethyl 6-(trifluoromethyl)tetrahydro-2H-pyran-3-carboxylate Ethyl 6-oxohexanoate ETHYL 2-(BROMOMETHYL)ACRYLATE ETHYL 2,3,4-TRI-O-BENZYL-1-THIO-BETA-L-FUCOPYRANOSIDE ETHYL 2-OXAZOLECARBOXYLATE 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 6-TERT BUTYL ESTER 3-ETHYL ESTER TERT-BUTYL FORMATE 6-BOC-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID (2-THIOPHEN-3-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER BUTTPARK 93\08-100 BUTTPARK 77\08-23 BUTTPARK 77\08-24
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