- 1-BOC-5-AMINO-INDAZOLE
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- $1.00
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2019-12-20
- CAS:129488-10-4
- Min. Order: 1KG
- Purity: 97-99%
- Supply Ability: 1000KGS
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| | 1-Boc-5-amino-indazole Basic information |
| Product Name: | 1-Boc-5-amino-indazole | | Synonyms: | 5-AMINO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;5-AMINO-1H-INDAZOLE-1-CARBOXYLIC ACID, 1,1 DIMETHYL ETHYL ESTER;1-Boc-5-Amino-1H-Indazole;tert-butyl 5-amino-1H-indazole-1-carboxylate;N-(1)-BOC-5-AMINO-INDAZOLE;1H-Indazol-5-amine, N1-BOC protected, tert-Butyl 5-amino-1H-indazole-1-carboxylate,5-Amino-1-(tert-butoxycarbonyl)-1H-indazole;1H-Indazole-1-carboxylicacid,5-aMino-,1,1-diMethylethylester;tert-butyl 5-aMino-1H-indazol-1-carboxylate | | CAS: | 129488-10-4 | | MF: | C12H15N3O2 | | MW: | 233.27 | | EINECS: | | | Product Categories: | Indazole;Building Blocks | | Mol File: | 129488-10-4.mol |  |
| | 1-Boc-5-amino-indazole Chemical Properties |
| Boiling point | 395.3±34.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | solid | | pka | 3.08±0.10(Predicted) | | Appearance | Brown to red Solid | | InChI | InChI=1S/C12H15N3O2/c1-12(2,3)17-11(16)15-10-5-4-9(13)6-8(10)7-14-15/h4-7H,13H2,1-3H3 | | InChIKey | LRSDPIIWOZRHNJ-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)C2=C(C=C(N)C=C2)C=N1 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 1-Boc-5-amino-indazole Usage And Synthesis |
| Uses | tert-Butyl 5-Amino-1H-indazole-1-carboxylate is an intermediate to prepare protein kinase inhibitors. | | Synthesis | General procedure for the synthesis of 5-amino-N-tert-butoxycarbonylindazole from 5-nitroindazole: 10% Pd-C catalyst (0.054 g, 0.051 mmol in Pd) and the carbamate from Example 105 (2.647 g, 10.1 mmol) were suspended in 95% ethanol, and the system was degassed under reduced pressure and the reaction was carried out under hydrogen atmosphere. After 23 hours of reaction, the solvent was removed using a rotary evaporator. Ethyl acetate (20 mL) was added to the reaction mixture and after filtration, the filtrate was slowly concentrated on a rotary evaporator to give 2.335 g (100% yield) of brown solid product.LC-MS (ESI) m/z 134 [M-Boc + H]+. | | References | [1] Patent: WO2006/135383, 2006, A2. Location in patent: Page/Page column 123-124
[2] Patent: WO2012/146724, 2012, A2
[3] Patent: US2014/57942, 2014, A1
[4] Patent: WO2014/68035, 2014, A1
[5] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7539 - 7543 |
| | 1-Boc-5-amino-indazole Preparation Products And Raw materials |
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