| Company Name: |
BOC Sciences
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info@bocsci.com |
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Product Name:NPC-15437 hydrochloride
CAS:141774-20-1
Purity:≥95% Remarks:NPC-15437 is a selective protein kinase C (PKC) inhibitor with IC50 value of 19 μM. It dose-dependently induced deficit of memory retention in mice as PKC signaling is involved in memory processes.
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| Company Name: |
Jinan ponder chemical co. LTD
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0531-0000 |
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Product Name:141774-20-1
CAS:141774-20-1
Purity:99% HPLC Package:1KG;500G;100G;50G;1G
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:NPC-15437 hydrochloride
CAS:141774-20-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride manufacturers
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| | (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Basic information |
| | (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble10mg/mL, clear | | form | powder | | color | white | | Water Solubility | H2O: 10mg/mL, clear | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
| | (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Usage And Synthesis |
| Description | NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 μM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4??Cell permeable.?Active?in vivo.4 | | Uses | N 161 is a selective protein kinase C (PKC) inhibitor. PKC is involved with signal transduction cascades related to immune response, cell growth, and memory. | | References | [1] J P SULLIVAN. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.[J]. Molecular Pharmacology, 1992, 41 1: 38-44.
[2] J P SULLIVAN. 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C.[J]. Agents and Actions, 1991, 34 1-2: 142-144. DOI:10.1007/bf01993261
[3] JAMES P. SULLIVAN. NPC 15437 interacts with the C1 domain of protein kinase C An analysis using mutant PKC constructs[J]. FEBS Letters, 1991, 285 1: Pages 120-123. DOI:10.1016/0014-5793(91)80739-p
[4] KAN MIYOSHI. mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption[J]. European journal of pharmacology, 2007, 562 3: Pages 208-211. DOI:10.1016/j.ejphar.2007.01.091 |
| | (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride Preparation Products And Raw materials |
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