Amifostine Thiol Dihydrochloride manufacturers
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| | Amifostine Thiol Dihydrochloride Basic information |
| | Amifostine Thiol Dihydrochloride Chemical Properties |
| Melting point | 184-186°C | | storage temp. | -20°C | | solubility | H2O: ≥20mg/mL | | form | powder | | color | white to off-white | | Water Solubility | H2O: ≥20mg/mL | | Stability: | Hygroscopic | | InChI | InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2 | | InChIKey | YHPLKWQJMAYFCN-UHFFFAOYSA-N | | SMILES | NCCCNCCS |
| Hazard Codes | Xn | | Risk Statements | 22-41 | | Safety Statements | 26-39-41 | | WGK Germany | 3 | | HS Code | 2930909165 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 | | Toxicity | mouse,LD50,intraperitoneal,400mg/kg (400mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 48, 1989. |
| | Amifostine Thiol Dihydrochloride Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A metabolite of Amifostine. | | Biochem/physiol Actions | WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. | | in vivo | The results show that Amifostine thiol dihydrochloride (Amifostine thiol) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that Amifostine thiol dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of Amifostine thiol dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats[3]. | | storage | Desiccate at -20°C |
| | Amifostine Thiol Dihydrochloride Preparation Products And Raw materials |
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