2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate manufacturers
- CLP290
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- $70.00
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2026-05-11
- CAS:1181083-81-7
- Purity: 99.93%
- Supply Ability: 10g
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| | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Basic information |
| Product Name: | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate | | Synonyms: | CLP 290;CLP290;2-([(5Z)-2-(1,2-DIAZINAN-1-YL)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-5-YLIDENE]METHYL)-5-FLUOROPHENYL PYRROL;2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate;CLP-290;(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate;[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine;1-Pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester;5-Fluoro-2-(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methylphenyl pyrrolidine-1-carboxylate | | CAS: | 1181083-81-7 | | MF: | C19H21FN4O3S | | MW: | 404.46 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 1181083-81-7.mol | ![2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Structure](CAS/20150408/GIF/1181083-81-7.gif) |
| | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Chemical Properties |
| Boiling point | 553.7±60.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO:23.74(Max Conc. mg/mL);58.7(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
Ethanol:2.02(Max Conc. mg/mL);4.99(Max Conc. mM) | | form | A crystalline solid | | pka | 1.29±0.20(Predicted) | | color | Off-white to yellow |
| | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Usage And Synthesis |
| Uses | CLP-290 is a chloride extrusion enhancer. | | in vivo | CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl- transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat[1]. | Animal Model: | Adult male rats (300g, >postnatal day 60)[1] | | Dosage: | 100 mg/kg | | Administration: | Oral gavage; 100 mg/kg; twice a day; 7day | | Result: | Rescued established MIH and prevented its development by restoring Cl-transport or preventing its deficiency in the SDH.
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| | storage | Store at -20°C |
| | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Preparation Products And Raw materials |
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